|
Demrow H S et al Administration of wine and grape juiceinhibits in vivo plateletactivity and thrombosis in stenosed canine coronary arteries. CIRCULATION 1995;91:1182-8.
The Folts model of mechanically stenosed coronary arteries in dogs was utilized to study periodic acute platelet-mediated thrombus formation which cause
cyclic flow reductions in coronary blood flow. Cyclic flow reductions (indirect measure of effect on platelet activity) in canine coronary blood flow were eliminated by:
- Dilute intravenous red wine and grape juice.
- Intragastric red wine and grape juice.
White wine did not significantly eliminate the cyclic flow reductions either intravenous or intragastric.
This University of Wisconsin-Madison research group had previously demonstrated that pure intravenous dilute ethanol inhibited platelets in this in vivo bioassay model but a blood alcohol concentration of 0.24 g/dL was required. Average blood alcohol concentration after elimination of the cyclic flow reductions by the intravenous red wine-saline solution was 0.028 g/dL.
The authors suggest that these results indicate antithrombotic compounds are present in red wine and grape juice that are not present (or in a lower
concentration) in white wine. Since the red wine and grape juice were also effective platelet inhibitors when administered intragastrically, the active ingredients must be absorbed into the circulation.
|
